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Contact SupplierPrograf (Tacrolimus) is a prescription medicine. This medication belongs to a class of drugs known as immunosuppressants. It is used together with other medicines to prevent your body from rejecting a heart, liver, or kidney transplant. It works by weakening your body's defense system (immune system) to help your body accept the new organ as if it were your own. Prograf is supplied as oral capsules, granules for oral suspension, and as an injection for intravenous use