Quad Mix Injection, Packaging Type : Box, Packaging Size : 10 Ml

QuadMiX Injection:
Papaverine HCl 150 mg, Phentolamine Mesylate 10 mg, Prostaglandin E1 100 mcg, Atropine Sulfate 1,000 mcg. Lyophilized.
Once reconstituted with 5 mL of Bacteriostatic Water: Papaverine HCl 30 mg/mL, Phentolamine Mesylate 2 mg/mL, Prostaglandin E1 20 mcg/mL, Atropine Sulfate 200 mcg/mL.

Super QuadMiX Injection:
Papaverine HCl 150 mg, Phentolamine Mesylate 20 mg, Prostaglandin E1 200 mcg, Atropine Sulfate 2,000 mcg. Lyophilized.
Once reconstituted with 5 mL of Bacteriostatic Water: Papaverine HCl 30 mg/mL, Phentolamine Mesylate 4 mg/mL, Prostaglandin E1 40 mcg/mL, Atropine Sulfate 400 mcg/mL.

General Information

QuadMix is administered as a penile self-injection, typically considered to be the most powerful class of anti-erectile dysfunction agents.1 While the components of QuadMix (Papaverine, Phentolamine, Prostaglandin E1, Atropine) are, on their own, indicated for a vast number of different conditions, the practice of bringing them together in concert to treat erectile dysfunction has become commonplace in sexual medicine21 and is now considered the go-to treatment if a patient is not responsive to conventional PDE5 inhibitors such as or Cialis.1 QuadMix is used in the treatment of erectile dysfunction in males. QuadMix contains four drugs from complimentary classes designed to act synergistically, mixed into a sterile injection. They are:

Papaverine HCl

A drug that causes blood vessels to expand (vasodilator); it produces an erection by allowing for increased blood flow to the . Papaverine interacts with adenylate cyclase resulting in increased cyclic adenosine monophosphate (cAMP) production, ultimately resulting in increased erectile capacity by relaxation of penile smooth muscle.3 This drug was one of the first effective therapies for erectile dysfunction administered by penile injection.4 Papaverine works by inhibiting phosphodiesterase nonspecifically, there are also multiple other mechanisms by which this drug acts to improve erectile capacity.

Biweekly intracavernous administration of papaverine for erectile dysfunction.9

Participants: 50 patients age 40 to 70 years old
Administration: intracavernosal injection at base of the
Dosage: 60 mg papaverine in 5 ml saline every 2 weeks
Results: Erection of 80% or more of normal was achieved by all but one patient, improves sexual potency

Medical treatment of impotence with papaverine and phentolamine intracavernosal injection.10

Participants: 20 patients age 32 to 72 years old
Administration: intracavernosal injection
Dosage: 30 mg papaverine and phentolamine 1 mg
Results: Response with erection in 20- 30 minutes, phentolamine and papaverine produced an erection sufficient for intercourse in 18 of the 20 subjects

Treatment of impotence by intrapenile injections of papaverine and phenoxybenzamine: a double blind, controlled trial.11

Participants: 39 patients age 27 to 67 years old
Administration: intracavernosal injection
Dosage: 60 mg Papaverine in 10 ml saline
Results: 35% full restoration of erectile capacity; 65% partial restoration of erectile capacity

Evaluating erectile dysfunction: oral sildenafil versus intracavernosal injection of papaverine:12

Participants: 39 patients age 21 to 65 years old
Administration: intracavernosal injection
Dosage: 30 mg papaverine
Results: Papaverine improved length and circumference papaverine is effective as injection therapy for erectile dysfunction