Sitagliptin, Form : Powder, Formula : C16H15F6N5O

Niksan Pharmaceutical is leading manufacturer and distributer of theSitagliptin among the other countries. Niksan Pharmaceutical is one of the major the supplier, distributer, exporter and manufacturer of the Sitagliptin API and finished formulations in Ankleshwar, Gujarat, India. The products of Niksan Pharmaceutical and Niksan group companies are widely appreciated by the clients and other companies.

Niksan Pharmaceutical is the supplier, manufacturer, exporter and trader of Sitagliptin in the domestic level as well as the international market. 

Niksan Pharmaceutical provides Sitagliptin API in all over Indian states like Jammu & Kashmir, Himachal Pradesh, Uttarakhand, Punjab, Kerala, Chandigarh, Chhattisgarh, Andhra Pradesh, Rajasthan, Meghalaya, Mizoram, Nagaland, Orissa, Pondicherry, Dadra and Nagar Haveli, Goa, Gujarat, Jharkhand, West Bengal, Karnataka, Kerala, Madhya Pradesh etc.

Niksan Pharmaceutical also provides Sitagliptin API and finished formulations in all other countries of the world like Germany, Switzerland, Poland, Latvia, Egypt, Lithuania, Estonia, Ukraine, Moldova, Russia, United States, Austria, Belarus, Serbia, India, Spain, Slovenia, Nigeria, Croatia, South Africa, Kazakhstan, Italy, Romania, Bulgaria, Portugal, South Korea, Greece, Philippines, Belgium, Saudi Arabia, Turkey, Japan etc.

Sitagliptin is one type of  medication. It works by increasing the amounts of certain natural substances that lower blood sugar when it is high.

SYNONYMS: Sitagliptin, Sitagliptina, Sitagliptine, Sitagliptinum

IUPAC NAME: (3R)-3-amino-1-[3-(trifluoromethyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one

CAS NO: 486460-32-6

FORMULA: C₁₆H₁₅F₆N₅O

MOLECULAR MASS:407.31 g/mol

STORAGE OF SITAGLIPTIN:Store sitagliptin at room temperature between 68°F and 77°F (20°C and 25°C). It can be stored briefly at a temperature between 59°F and 86°F (15°C and 30°C). Store this drug away from light.

APPLICATIONS OF SITAGLIPTIN:Sitagliptin is used along with diet and exercise and sometimes with other medications to lower blood sugar levels in adults with type 2 diabetes (condition in which blood sugar is too high because the body does not produce or use insulin normally).

HOW TO USE: Sitagliptin comes as a tablet to take by mouth. It is usually taken once a day with or without food. Take sitagliptin at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand.

HOW SITAGLIPTIN WORKS: Sitagliptin is prescribed for people who still have high blood sugar, even though they have a sensible diet and exercise regularly. It works by increasing the amount of insulin that your body makes. Insulin is the hormone that controls sugar levels in your blood. Sitagliptin is only available on prescription.

CONTRAINDICATIONS OF SITAGLIPTIN: Sitagliptin is contraindicated in patients with a known sitagliptin hypersensitivity, such as anaphylaxis, urticaria, angioedema, exfoliative dermatitis or other serious skin conditions (serious rash), including Stevens-Johnson syndrome.

PHARMACOKINETICS OFSITAGLIPTIN: Sitagliptin improves glycemic control by inhibiting DPP-4 inactivation of GLP-1 and glucose-dependent insulinotropic ploypeptide. Inhibition of DPP-4 increases and prolongs the activity level of incretin, leading to a glucose-dependent increase in insulin release and a decrease in glucagon [7].

SIDE EFFECTS OF SITAGLIPTIN:  The most common side effect of sitagliptin, which happens in more than 1 in 100 people, is headaches. Talk to your doctor if headaches last longer than a week or are severe. If taking sitagliptin gives you a headache, make sure you rest and drink plenty of fluids. Do not drink too much alcohol.