Tobramycin

TOBRAMYCIN IS WIDELY ADMINISTERED AMINO GLYCOSIDE ANTIBIOTIC FOR OCULAR INFECTIONS BECAUSE OF ITS EFFICIENCY TO ELIMINATE GRAM-NEGATIVE BACTERIA ESPECIALLY PSEUDOMONAS SPECIES. IT IS PREFERRED DUE TO ITS BROAD SPECTRUM THAT COVERS STRAINS RESISTANT TO GENTAMYCIN. TOBRAMYCIN READILY BINDS WITH THE RIBOSOMAL PAIR DISABLING IT TO PRODUCE M-RNA RESPONSIBLE FOR THE PROTEIN FORMATION IN BACTERIA THUS ENSURING CELL DEATH. IT ALSO DESTABILIZES THE BACTERIAL MEMBRANE BY BINDING THE 16S R-RNA THUS THE FUNCTIONAL INTEGRITY OF THE BACTERIAL CELL MEMBRANE APPEARS TO BE DISRUPTED.