Trustiva Tablet, Composition : Tenofovir Disoproxil Fumarate

Trustiva Tablets are a fixed-dose combination of three antiviral medicines used for the treatment of Human Immunodeficiency Virus (HIV) type 1 infection.This medication is a part of combination antiretroviral therapy (ART) and works by helping to control the virus, reduce the viral load, and improve immune function.

 

 

Active Ingredients

 

Trustiva tablets contain a combination of three active ingredients:

 

• Efavirenz (600 mg): A non-nucleoside reverse transcriptase inhibitor (NNRTI).

   
   

   

• Emtricitabine (200 mg): A nucleoside reverse transcriptase inhibitor (NRTI).

   

   

• Tenofovir Disoproxil Fumarate (300 mg): A nucleotide reverse transcriptase inhibitor (NtRTI).

   
   

   

These drugs work together to block a critical enzyme called reverse transcriptase, which the HIV virus needs to replicate.By stopping this process, Trustiva helps to reduce the amount of virus in the body and strengthens the immune system to fight off infections.

 

 

Key Uses

 

• Treatment of HIV-1 infection: Trustiva is used as a complete regimen or in combination with other antiretroviral agents for adults and adolescents with HIV-1 infection.

   

   

• Viral Suppression: It helps to reduce the viral load, which is the amount of HIV in the blood, and prevent the progression of HIV to AIDS.

   

   

 

Dosage and Administration

 

• The typical dosage for adults and adolescents weighing at least 40 kg is one tablet once a day.

   

   

• It is generally recommended to take Trustiva on an empty stomach, preferably at bedtime.Taking it at bedtime can help to reduce common side effects like dizziness and trouble sleeping.

   
   

   

• It is crucial to take the medication regularly and not skip doses to prevent the virus from developing drug resistance.

   

   

 

Common Side Effects

 

While Trustiva is effective, it can cause various side effects. These may include:

 

• Dizziness, drowsiness, and fatigue

   

   

• Gastrointestinal issues such as nausea, vomiting, and diarrhea

   

   

• Headache

   

   

• Skin rash

   

   

• Abnormal dreams or nightmares

   

   

 

Warnings and Precautions

 

• Mental Health: This medication can cause serious psychiatric side effects, including severe depression, anxiety, hallucinations, and suicidal thoughts. Patients with a history of mental illness should be closely monitored.

   

   

• Kidney and Liver Health: Trustiva can affect kidney and liver function.Regular monitoring of these organs with blood tests may be necessary.

   
   

   

• Bone Density: Long-term use of Tenofovir can lead to a decrease in bone mineral density.Your doctor may recommend calcium and vitamin D supplements.

   
   

   

• Pregnancy: Trustiva may cause birth defects.It is critical for women of childbearing potential to use effective contraception during treatment and for 12 weeks after stopping the medication.

   

   

• Drug Interactions: Trustiva can interact with other medications, including certain antifungals, anticonvulsants, and herbal supplements like St. John's wort. Always inform your doctor about all the medicines you are taking