Vaccinate Inactivated Influenza Vaccine

Influenza Vaccine (Split Virion), InactivatedInfluenza Vaccine (Split Virion) is a preparation made from the prevalent strains of influenza virus type A and type B recommended by WHO and approved by the NRA. The strains of influenza virus type A and type B are grown separately in embryonated chicken eggs. After cultivation, the virus suspensions in allantoic cavities are harvested, inactivated, purified,disrupted and repurified to make the vaccine. It is used to prevent the infections of the prevalent strains of influenza viruses.1 Basic requirementsThe facilities, source and subsidiary materials, water, apparatus and animals used for production and control tests of biologics shall comply with the requirements set forth in the General Notices.2 Manufacturing2.1 Embryonated eggs for vaccine productionSpecific pathogen free (SPF) chick embryos shall be used for the preparation and passage of virus seeds. The embryonated eggs derived from closed healthy flocks shall be used for the vaccine production. The embryos of 9-11 days old shall be in active status with vivid blood vessels and free of any aberrations.2.2  Virus seeds2.2.1  Name and origin of virus strainsThe virus seeds used for the vaccine production shall be the approved strains of influenza type A and type B viruses recommended and supplied by the WHO.2.2.2  Establishment of seed lot systemIt complies with the Requirements for Bacterial and Virus Strains Seeds