Zoledronic Acid

We are offering zoledronic acid anhydrous is a bisphosphonate. The chemical classifi- cation of zoledronic acid anhydrous is diphosphonates anhydrous form of a synthetic imidazole third generation bisphosphonate analog of pyrophosphate with antiresorptive activity. Zoledronate binds to hydroxyapatite crystals in the bone matrix & inhibits farnesyl pyro- phosphate (diphosphate) synthase, thereby preventing protein preny- lation within the mevalonate pathway. This leads to the loss of downs-tream metabolites essential for osteoclast function, leading to the induction of apoptosis and eventually, osteoclast-cell death. By pre- venting osteoclast-mediated bone resorption zoledronate decreases bone turnover and stabilizes the bone matrix.
synonyms: (1-hydroxy-2-imidazol-1-yl-1-phosphonoethyl) phosphonic acid
cas number: 118072-93-8, mol. Formula: c5h10n2o7p2, mol.weight: 272.09
zoledronic acid is a white solid powder. It is soluble in dmso (0.004 mgml at 25 °c), water (