TURMIX is a synergistic combination of Curcumin & Piperine for prevention & treatment of various chronic conditions including Pre-cancerous lesions (Sub-mucous fibrosis, Oral Leukoplakia, Lichen Planus), Cancer, Rheumatoid arthritis, Dermatitis and other inflammatory conditions.

TURMIXis a synergistic combination of Curcumin & Piperine for prevention & treatment of various chronic conditions including Pre-cancerous lesions (Sub-mucous fibrosis, Oral Leukoplakia, Lichen Planus), Cancer, Rheumatoid arthritis, Dermatitis and other inflammatory condition.

Curcumin

• Anti-Inflammatory
  
  
  Research shows Curcumin is highly pleiotropic molecule capable of interacting with numerous molecular targets involved in inflammation. Curcumin modulates the inflammatory response by down-regulating the activity of Cyclooxygenase-2 (COX-2), Lipoxygenase, and inducible Nitric Oxide Synthase (iNOS) enzymes; inhibits the production of the inflammatory Cytokines- Tumor Necrosis Factor-alpha (TNF-a), interleukin (IL) -1, -2, -6, -8, and -12.

• Anti-Oxidant
  
  
  Curcumin is a potent scavenger of reactive oxygen species (ROS) including Superoxide anion, Nitric oxide & Hydroxyl radicals. In various clinical studies, it has been shown that Curcumin increases levels of vitamin C & E in saliva & prevents lipid peroxidation & DNA damage.

• DNA Protecting
  
  
  Curcumin inhibits NF-KB & various other chemical mediators responsible for DNA damage & disease progression. Curcumin is also found to protect DNA by preventing interaction of DNA with various Carcinogens.

• Anti Fibrotic
  
  
  Curcumin inhibits proliferation of fibroblasts and myofibroblasts; it also disturbs the cell cycle, induces apoptosis and decreases the generation of collagen type I and III in myofibroblasts.

• Anti-Carcinogenic
  
  
  Curcumin exerts clinically relevant anti-cancer effects & opens up a new avenue for chemoprevention & treatment of Oral, Skin, Colorectal, Breast & other types of cancers. Curcumin induces apoptosis, inhibits cell cycle progression, invasion & metastatis by blocking NF-KB & other molecular factors.

• Immunomodulator
  
  
  Curcumin shows potent immunomodulatory action that can modulates the activation of T cells, B cells, Macrophages, Neutrophils, Natural killer cells, and Dendritic cells. Curcumin can also downregulate the expression of various pro-inflammatory Cytokines including TNF, Interleukins and Chemokines. Interestingly, Curcumin can also enhance antibody responses.

Piperine: Nature's Best Bioavailability Enhancer

1. Inhibits hepatic & intestinal glucuronidation of Curcumin


2. Increases bioavailability of Curcumin by 2000% in humans with no adverse effects

• Pre-cancerous lesions
  
  
  
  
  
  
  
  • Sub-mucous fibrosis,
  
  
  
  
  
  
  
  
  
  
  
  
  • Oral Leukoplakia
  
  
  
  
  
  
  
  
  
  
  • Lichen planus
  
  
  
  

• Other oral lesions: Gingivitis / Periodontitis / stomatitis

• Cancer (Oral / Lung / Head & Neck / Prostate / Cervical Cancer etc.)

• Rheumatoid Arthritis / Osteoarthritis

• Skin disorders (Psoriasis / Eczema)

• Cough / Cold /Bronchitis

• Liver Problems / IBS

• Adjuvant Therapy in Malaria

Dianova (Berberine 500mg) is used in Diabetes mellitus by increasing the glucose uptake inside the cells, insulin sensitizing effect, incretin effects and by DDP4 inhibition.

• Improving insulin action by activating AMP-activated protein kinase AMPK (Metabolic Master Switch)

• Improves glucose metabolism through induction of Glycolysis

• Promoting GLP-1 (Incretins) secretion and modulating its release
  
  
  (Incretins) cause short-term increase in the amount of Insulin

• Inhibition of DPP-4 , similar to Sitagliptin
  
  
  Dipeptidyl peptidase-4 (DPP-4) is the enzyme responsible for inactivation of Incretins


• 
  Indications
  
  
  
  
  
  • Diabetes
  
  
  • Diabetic Neuropathy
  
  
  • CVD
  
  
  • Dyslipidemia
  
  
  • Fatty liver disease
  
  
  • PCOS
  
  
  
  
  
  
  
  Dosage and directions for use
  

  
  

  1 capsule twice in a Day

  
  

  
  CONTRA-INDICATIONS:
  

  
  

  Hypersensitivity to ingredient.

  
  

  
  Storage:
  

  
  

  Store in a cool, dark & dry place keep out of reach of children.

  
  
  
  
  
  DRUG INTERACTIONS:
  

  
  

  Should be avoided in patients taking macrolide
  antibiotics like azithromycin, clarithromycin
  and Immunosuppressant, Cyclosporins

  
  

  
  SIDE-EFFECTS:
  

  May cause gastric discomfort in sensitive individuals
  in initial days of use which subsides gradually .

  
  
  
  

NUNERVE-LMis an ideal composition of L-Carnitine fortified with Mecobalamin, Folic Acid, Grape seed extract, Vitamin E, Pyridoxine HCL & Vitamin D3. Ideal for Diabetes, Cardiovascular diseases, muscle/leg cramps, fatigue/weakness etc.

• L-Carnitine: Important contributor to cellular energy metabolism
  
  
  L-carnitine is an amino acid (a building block for proteins), naturally produced in the body. It provides support for nervous system, cardiovascular system and muscles.
  
  
  How does it work?
  
  
  L-carnitine helps the body produce energy. L-carnitine is indispensable for the transport of long-chain fatty acids across the inner mitochondrial membrane to their site of oxidation & the production of energy in the form of ATP. It is important for heart and brain function, muscle movement, and many other body processes.

• Methylcobalamin, Folic Acid & Pyridoxine
  
  
  Lowers total homocysteine level (Hyper- homocysteinemia) in hemodialysis patients.Hyperhomocysteinemia is a possible risk factor for coronary artery disease. Mecobalamin also prevent & treat symptoms of diabetic neuropathy & CVDs.

• Grape seed Extract
  
  
  Grape seed extract - or the chemicals within them, especially oligomeric proanthocyanidin complexes (OPCs) -- have been touted as powerful antioxidants. Vitamin E, flavonoids, linoleic acid, and OPCs are highly concentrated in grape seeds.

• Vitamin D
  
  
  Potential mechanism & beneficial effects of Vitamin D on Diabetes:
  
  
  
  
  
  1. Effect of Vitamin-D on Insulin secretion:Promote conversion of Pro-insulin to insulin, increases insulin output
  
  
  
  
  
  
  
  
  1. Protection of Beta cells:Prevents beta cell damage by inhibiting the synthesis of inflammatory cytokines
  
  
  
  
  
  
  
  
  1. Improve insulin sensitivity& promote beta cell survival by modulating effects of cytokines.
  
  
  
  
  
  
  
  
  1. Improve glucose tolerance.
  
  

• Vitamin E
  
  
  Vitamin E is an antioxidant that occurs naturally in foods such as nuts, seeds, and leafy green vegetables. Vitamin E is a fat-soluble vitamin important for many processes in the body.
  
  
  Uses:
  
  
  
  
  
  1. Vitamin E & L-Carnitine reduces frequency of muscle/leg cramps more effectively as compared to monotherapy.
  
  
  
  
  
  
  
  
  1. Protect cell membrane and tissues from oxidative damage
  
  
  
  
  
  
  
  
  1. Promotes healthy circulatory system.
  
  
  2. 
     Indications
     
     
     
     
     
     • Diabetes & CVD
     
     
     • Diabetic/Peripheral Neuropathy
     
     
     • Drug/Alcohol Induced Neuropathy
     
     
     • Fatigue/Weakness
     
     
     • Muscle/Leg cramps
     
     
     • Hemodialysis patients
     
     
     
     
     
     
     
     Dosage
     

     
     

     1-2 tablets / Day

     
     

     
     Side-Effects
     

     
     

     No known side effects have been reported.

     
     
     
     
     
     Presentation:
     

     
     

     10 tablets in a strip

     
     

     
     Storage Instructions:
     

     store in a cool, dark & dry place
     keep out of reach of children.

     
     
     
     
  
  

Cessation of menstruation is menopause. It is a genetically programmed arrest of ovarian function. Around 50 years, a woman's body starts to change. After a long career of producing eggs and estrogen, the ovaries take an early retirement and the body goes through the hormone withdrawal process - menopause. The average age of menopause is 51 years old, although this varies. At menopause a woman's level of estrogen and progesterone, hormones that cause menstruation, decrease and thus menstruation ceases.

Cessation of menstruation is menopause. It is a genetically programmed arrest of ovarian function.

Around 50 years, a woman's body starts to change. After a long career of producing eggs and estrogen, the ovaries take an early retirement and the body goes through the hormone withdrawal process - menopause. The average age of menopause is 51 years old, although this varies. At menopause a woman's level of estrogen and progesterone, hormones that cause menstruation, decrease and thus menstruation ceases.

After menopause (post menopause) there is an increased risk of osteoporosis because estrogen hormone depletes. Although all women are affected by menopause, some women don't experience menopausal symptoms, while others benefit from the medical treatment of the symptoms.

For management of Thrombocytopenia (Low Platelet Count) due to Dengue, Malaria, Viral, Chemotherapy, Liver Cirrhosis, ITP etc.

Thrombocytopenia is a lower than normal number of platelets (Low Platelet Count) in the blood. The number of platelets in the blood is referred to as the platelet count and is normally between 150, 000 to 450, 000 per micro liter (one millionth of a liter) of blood. Platelet counts less than 150, 000 are termed thrombocytopenia.

Bleeding of the gums, nosebleeds, rash (red, pinprick-sized spots on the skin), skin discoloration such as bruising, severe or uncontrollable bleeding (severe symptom).

Carica papaya is a rich source of complex biochemical constituents including flavonoids, glycosides, alkaloids, glutathione & glucosinolates that helps boost the number of platelets by stimulating bone marrow. C. papaya increases ALOX-12 & PTAFR gene expression by 15 & 13.42 folds that further boost the platelet count by increasing megakaryocytic production. It can also prevent platelet destruction in the blood and thereby increase the life of the platelet in circulation.

Carica papaya & Tinospora cordifolia extracts show immunomodulatory activity. Various studies have shown T. cordifolia exhibit increase in the WBC counts & bone marrow cells significantly indicating stimulatory effect on entire haemopoetic system.