SHIVRUDRA PHARMACEUTICALS PVT. LTD

Katargam, Surat, Gujarat

We are a leading Manufacturer, Exporter, Supplier, and Trader offering high-quality Etomidate USP Powder. Our air-proof packaging ensures product freshness. This powder, with the formula CHNO, has a shelf life of 3 years. The product is identified by the case number 33125-97-2. Trust us for premium quality and reliable supply of this essential product.

Etomidate API Powderis the active pharmaceutical ingredient used in the formulation of etomidate-based medications, primarily as an intravenous anesthetic agent. It is a white to off-white crystalline powder, typically used in hospital and clinical settings for the induction of general anesthesia and sedation in critically ill patients. Etomidate acts by enhancing the activity of GABA, a major inhibitory neurotransmitter in the central nervous system, leading to rapid onset of sedation with minimal cardiovascular effects. Due to its favorable safety profile, it's often preferred for patients with hemodynamic instability. The API must be handled with care and used under strict medical guidelines.

TriMix is so named because it is a compounded drug comprised of a mixture of three drugs namely phentolamine, papaverine and alprostadil in varying concentrations. This drug is not readily available in traditional retail pharmacies but must be specially made at compounding pharmacies. The components of TriMix have been shown to exert a synergistic effect in causing sustained penile erections in individuals suffering from ED. In contrast to the first-line drug treatment of ED, PDE5 inhibitors, which are administered orally, TriMix is an injectable medication which is administered locally into the penis. This medication is typically compounded at dosages that are tailored to the requirements of each individual. Discussed below are more details about the components of TriMix injection.

Dosage Strengths of QuadMix Injection

QuadMiX Injection:Papaverine HCl 150 mg, Phentolamine Mesylate 10 mg, Prostaglandin E1 100 mcg, Atropine Sulfate1, 000 mcg. Lyophilized.Once reconstituted with 5 mL of Bacteriostatic Water: Papaverine HCl 30 mg/mL, Phentolamine Mesylate 2 mg/mL, Prostaglandin E1 20 mcg/mL, Atropine Sulfate200 mcg/mL.

SuperQuadMiX Injection:Papaverine HCl 150 mg, Phentolamine Mesylate 20 mg, Prostaglandin E1 200 mcg, Atropine Sulfate2, 000 mcg. Lyophilized.Once reconstituted with 5 mL of Bacteriostatic Water: Papaverine HCl 30 mg/mL, Phentolamine Mesylate 4 mg/mL, Prostaglandin E1 40 mcg/mL, Atropine Sulfate400 mcg/mL.

General Information

QuadMixis administered as a penile self-injection, typically considered to be the most powerful class of anti-erectile dysfunction agents.1While the components of QuadMix (Papaverine, Phentolamine, Prostaglandin E1, Atropine) are, on their own, indicated for a vast number of different conditions, the practice of bringing them together in concert to treat erectile dysfunction has become commonplace in sexual medicine21and is now considered the go-to treatment if a patient is not responsive to conventional PDE5 inhibitors such as Viagra or Cialis.1QuadMix is used in the treatment of erectile dysfunction in males. QuadMix contains four drugs from complimentary classes designed to act synergistically, mixed into a sterile injection. They are:

Papaverine HCl

A drug that causes blood vessels to expand (vasodilator); it produces an erection by allowing for increased blood flow to the penis. Papaverine interacts with adenylate cyclase resulting in increased cyclic adenosine monophosphate (cAMP) production, ultimately resulting in increased erectile capacity by relaxation of penile smooth muscle.3This drug was one of the first effective therapies for erectile dysfunction administered by penile injection.4Papaverine works by inhibiting phosphodiesterase nonspecifically, there are also multiple other mechanisms by which this drug acts to improve erectile capacity.

Biweekly intracavernous administration of papaverine for erectile dysfunction.9

Participants:50 patients age 40 to 70 years oldAdministration:intracavernosal injection at base of the penisDosage:60 mg papaverine in 5 ml saline every 2 weeksResults:Erection of 80% or more of normal was achieved by all but one patient, improves sexual potency

Medical treatment of impotence with papaverine and phentolamine intracavernosal injection.10

Participants:20 patients age 32 to 72 years oldAdministration:intracavernosal injectionDosage:30 mg papaverine and phentolamine 1 mgResults:Response with erection in 20- 30 minutes, phentolamine and papaverine produced an erection sufficient for intercourse in 18 of the 20 subjects

Treatment of impotence by intrapenile injections of papaverine and phenoxybenzamine: a double blind, controlled trial.11

Participants:39 patients age 27 to 67 years oldAdministration:intracavernosal injectionDosage:60 mg Papaverine in 10 ml salineResults:35% full restoration of erectile capacity; 65% partial restoration of erectile capacity

Evaluating erectile dysfunction: oral sildenafil versus intracavernosal injection of papaverine:12

Participants:39 patients age 21 to 65 years oldAdministration:intracavernosal injectionDosage:30 mg papaverineResults:Papaverine improved length and circumference papaverine is effective as injection therapy for erectile dysfunction

Dosage Strengths of BiMix Injection

BiMiX Injection: Papaverine HCl 150 mg, Phentolamine Mesylate 5 mg. Lyophilized.Once reconstituted with 5 mL of Bacteriostatic Water: Papaverine HCl 30 mg/mL, Phentolamine Mesylate 1 mg/mL.
Super BiMiX Injection:Papaverine HCl 150 mg, Phentolamine Mesylate 10 mg. Lyophilized.Once reconstituted with 5 mL of Bacteriostatic Water: Papaverine HCl 30 mg/mL, Phentolamine Mesylate 2 mg/mL.

General Information

BiMix is administered as a penile self-injection, typically considered to be a powerful class of anti-erectile dysfunction agents.1While the components of BiMix (Papaverine, Phentolamine) are, on their own, indicated for a vast number of different conditions, the practice of bringing them together in concert to treat erectile dysfunction has become commonplace in sexual medicine and is now considered the go-to treatment if a patient is not responsive to conventional PDE5 inhibitors.12BiMix is used in the treatment of erectile dysfunction in males. BiMix contains two drugs from complimentary classes designed to act synergistically, mixed into a sterile injection. They are:

Reasons Not to Take This Medicine

Do not take this medicine with any of the following medications: hypersensitivity or allergy to any component of this formulation; conditions predisposing you to priapism (painful erection lasting 4 hours or more): sickle cell anemia, multiple myeloma or leukemia; anatomical deformation of the penis or penile implants; direction by your physician that sexual activity is inadvisable or contraindicated

QuadMiX Injection:Papaverine HCl 150 mg, Phentolamine Mesylate 10 mg, Prostaglandin E1 100 mcg, Atropine Sulfate1, 000 mcg. Lyophilized.Once reconstituted with 5 mL of Bacteriostatic Water: Papaverine HCl 30 mg/mL, Phentolamine Mesylate 2 mg/mL, Prostaglandin E1 20 mcg/mL, Atropine Sulfate200 mcg/mL.

SuperQuadMiX Injection:Papaverine HCl 150 mg, Phentolamine Mesylate 20 mg, Prostaglandin E1 200 mcg, Atropine Sulfate2, 000 mcg. Lyophilized.Once reconstituted with 5 mL of Bacteriostatic Water: Papaverine HCl 30 mg/mL, Phentolamine Mesylate 4 mg/mL, Prostaglandin E1 40 mcg/mL, Atropine Sulfate400 mcg/mL.

General Information

QuadMixis administered as a penile self-injection, typically considered to be the most powerful class of anti-erectile dysfunction agents.1While the components of QuadMix (Papaverine, Phentolamine, Prostaglandin E1, Atropine) are, on their own, indicated for a vast number of different conditions, the practice of bringing them together in concert to treat erectile dysfunction has become commonplace in sexual medicine21and is now considered the go-to treatment if a patient is not responsive to conventional PDE5 inhibitors such as Viagra or Cialis.1QuadMix is used in the treatment of erectile dysfunction in males. QuadMix contains four drugs from complimentary classes designed to act synergistically, mixed into a sterile injection. They are:

Papaverine HCl

A drug that causes blood vessels to expand (vasodilator); it produces an erection by allowing for increased blood flow to the penis. Papaverine interacts with adenylate cyclase resulting in increased cyclic adenosine monophosphate (cAMP) production, ultimately resulting in increased erectile capacity by relaxation of penile smooth muscle.3This drug was one of the first effective therapies for erectile dysfunction administered by penile injection.4Papaverine works by inhibiting phosphodiesterase nonspecifically, there are also multiple other mechanisms by which this drug acts to improve erectile capacity.

Biweekly intracavernous administration of papaverine for erectile dysfunction.9

Participants:50 patients age 40 to 70 years oldAdministration:intracavernosal injection at base of the penisDosage:60 mg papaverine in 5 ml saline every 2 weeksResults:Erection of 80% or more of normal was achieved by all but one patient, improves sexual potency

Medical treatment of impotence with papaverine and phentolamine intracavernosal injection.10

Participants:20 patients age 32 to 72 years oldAdministration:intracavernosal injectionDosage:30 mg papaverine and phentolamine 1 mgResults:Response with erection in 20- 30 minutes, phentolamine and papaverine produced an erection sufficient for intercourse in 18 of the 20 subjects

Treatment of impotence by intrapenile injections of papaverine and phenoxybenzamine: a double blind, controlled trial.11

Participants:39 patients age 27 to 67 years oldAdministration:intracavernosal injectionDosage:60 mg Papaverine in 10 ml salineResults:35% full restoration of erectile capacity; 65% partial restoration of erectile capacity

Evaluating erectile dysfunction: oral sildenafil versus intracavernosal injection of papaverine:12

Participants:39 patients age 21 to 65 years oldAdministration:intracavernosal injectionDosage:30 mg papaverineResults:Papaverine improved length and circumference papaverine is effective as injection therapy for erectile dysfunction

Etomidate API Powder is a high-purity pharmaceutical active ingredient widely used as a short-acting intravenous anesthetic agent. It is primarily utilized for the induction of general anesthesia and procedural sedation, especially in patients where cardiovascular stability is critical.

This API is known for its rapid onset of action, minimal hemodynamic effects, and reliable anesthetic performance. Etomidate is extensively used in hospital settings, emergency medicine, and intensive care units for controlled sedation.

The product is manufactured under stringent quality standards, ensuring consistent particle size, excellent stability, and compliance with international pharmaceutical specifications. Etomidate API Powder is suitable.