Quinidine

We are offering quinidine is an antiarrhythmic and cytochrome p450 2d6 inhibitor. The mechanism of action of quinidine is as a cytochrome p450 2d6 inhibitor. Quinidine is an extracted from the bark of the cinchona tree with class 1a antiarrhythmic and antimalarial effects. Quinidine stabilizes the neuronal membrane by binding to and inhibiting voltage-gated sodium channels, thereby inhibiting the sodium influx required for the initiation and conduction of impulses resulting in an increase of the threshold for excitation and decreased depolarization during phase 0 of the action potential. In addition, the effective refractory period (erp), action potential duration (apd), and erpapd ratios are increased, resulting in decreased conduction velocity of nerve impulses. quinidine exerts its antimalarial activity by acting primarily as an intraeryth rocytic schizonticide through association with the heme polymer (hemazoin) in the acidic food vacuole of the parasite thereby preventing further polymerization by heme polymerase enzyme. This results in accumulation of toxic heme and death of the parasite.
synonyms: (s)-[(2r, 4s, 5r)-5-ethenyl-1-azabicyclo [2.2.2] octan-2-yl]-(6-methoxyquinolin-4-yl) methanol
cas number: 56-54-2, mol. Formula: c20h24n2o2, mol.weight: 324.42
quinidine is white to light yellow crystal powder. It is soluble in methanol, chloroform, alcohol (1 g36ml), water (140 mgl) at 25 °c, benzene, dmso(100mm), and slightly soluble in ether, petroleum ether with melting range of 168°c to 172°c.
standard: offered of pharmaceutical grade bpuspep
packing: offered in export worthy packing of 25 kilos or as per our customer requirements