Delta Sleep-inducing Peptide DSIP

Discovery
Delta sleep-inducing peptide was first discovered in 1974 by the Swiss Schoenenberger-Monnier group who isolated it from the cerebral venous blood of rabbits in an induced state of sleep. It was primarily believed to be involved in sleep regulation due to its apparent ability to induceslow-wave sleep in rabbits, but studies on the subject have been contradictory.
Delta-sleep-inducing peptide (DSIP)-like material has been found in human breast milk
Delta sleep-inducing peptide(DSIP) Basic Info.
Sequence:r-l-Gly-Gly-Asp-Ala-Ser-Gly-Glu
Specification: 2mgvial;
CAS No: 62568-57-4
Formula: C35H48N10O15
Molecular Weight: 848.81
Purity: 99.0%min
DSIP Function
Many roles for DSIP have been suggested following research carried out using peptide analogues with a greater molecular stabilityand through measuring DSIP-like immunological (DSIP-LI) response by injecting DSIPantiserum and antibodies.
Roles in endocrine regulation
Decreases basal corticotropin level and blocks its release.
Stimulates release of luteinizing hormone (LH).
Stimulates release of somatoliberin and somatotrophin secretion and inhibits somatostatin secretion.
Delta sleep-inducing peptide, abbreviated DSIP, is a neuropeptide that when infused into the mesodiencephalic ventricle of recipient rabbits induces spindle and delta EEG activity and reduced motor activities.
Delta sleep-inducing peptide was first discovered in 1974 by the Swiss Schoenenberger-Monnier group who isolated it from the cerebral venous blood of rabbits in an induced state of sleep. It was primarily believed to be involved in sleep regulation due to its apparent ability to induce slow-wave sleep in rabbits, but studies on the subject have been contradictory.