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Min. Order (MOQ)
25 Kilogram
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Number Of Flower
WHITE CRYSTALLINE POWDER
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CAS No.
57248-88-1
Pamidronate disodium is the disodium salt of the synthetic bisphospho- nate pamidronate. Although its mechanism of action is not completely understood, pamidronate appears to adsorb to calcium phosphate crystals in bone, blocking their dissolution by inhibiting osteoclast-mediated bone resorption. This agent does not inhibit bone mineralization and formation.Pamidronate disodium salt is a bisphosphonate compound, which inhibits farnesyl diphosphate synthase & bone resorption. Studies suggest that pamidronate disodium salt stimulates polymorphonuclear leukocyte and platelet derived nitric oxide production. It is believed that this nitric oxide production can lead to a negative feedback mechanism, which could restrict the inflammatory process and reduce bone resorption. Furthermore, bisphosphonates induce endothelial cell death, cancer cell apoptosis, and nuclear factor-b pathway activation, via the endothelial protein c receptor.
GST : 27AGPPS8689E1ZF
4.5/5
Mr. Ashok Shah (UMA Brothers)
C-110, Bhaveshwar Plaza, 189, LBS Marg, Ghatkopar West., Mumbai, Maharashtra - 400086, India
https://www.umabrothers.com
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