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Zafirlukastis an orally administeredleukotriene receptor antagonist(LTRA) used for the chronic treatment ofasthma. While zafirlukast is generally well tolerated, headache and stomach upset often occur. Some rare side effects can occur, which can be life-threatening, such asliver failure.Churg-Strausssyndrome has been associated with zafirlukast, but the relationship isn't thought to be causative in nature. Overdoses of zafirlukast tend to be self-limiting.
Zafirlukast isFDA-approved for the prevention and treatment of asthma in adults and children older than 5 years old.Like other leukotriene receptor antagonists, zafirlukast is thought to be useful for the long-term treatment of asthma, but it is generally less effective than inhaled glucocorticoids as monotherapy (which are the standard of care) or long-acting beta-2 agonists in combination therapy.Notably, zafirlukast is ineffective in the event of an acute asthma attack.
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