PRISM PHARMA MACHINERY

Vatva, Ahmedabad, Gujarat

High Precision Fluidize Drying, Granulating, Agglomerating & Coating Process Technology

Application & Process :

Prism Fluid Bed Processing involves drying, cooling, agglomeration, granulation and coating of particulate materials. It is ideal for heat sensitive and non heat sensitive products in Pharmaceuticals, Biotech, Nutraceuticals, Cosmetic, Chemicals, Biochemical, Food, Dairy, Confectionery, Agrochemical, Herbals, Ceramics, Detergents and Pharma Institutes.

Depending on the application required Prism fluid bed Equipment can be configured into designs as follows :

1. The Fluid Bed Mixing and Drying Process :The Fluid Bed system have a bed of solid particles which are fluidized by passing a stream of air upward through a specially designed perforated sheet. The upward velocity of air is so maintained so as to slightly lift the solid particles and set them in motion. This motion can be utilized to bring about mixing as well as forward movement of the solids particles. The air is heated and the process hot air evaporates the fluid and dries the solids. Fines get agglomerated to larger granules particles thus providing large size

2. The Fluid Bed Processor with Top spraying system for Agglomeration and Granulation Process :The process is used in fluid beds to form granules form a fine powder. The fluidized powder is wetted with fluid / binder / starch pest by using top spraying system. The top spraying system provided with spraying nozzle and precise dosing peristaltic pump. The fluidized powder is wetted until liquid bridges are formed between particles. Segregation of powder doesn't take place as different powder is glued together on a micro scale. Since there is no impinging force in fluid bed equipments the granules are weak and having good solubility. Once the granules are made they are dried in the equipment using hot air. This technology used for formed granules for Tabletting, capsule, dust free process, free flow properties, good dispensability and excellent solubility due to porous structure.

3. Fluid Bed Equipment with Wurster Coater Bottom Spray for Granules Coating or Pellet Coating :The Coater is capable of handling any of the following process.

• Aqueous or Solvent based solutions or suspensions
• Controlled release coatings
• Enteric Release coatings
• Fine particle coatings
• Active layering

This process is used to apply a coating to the granules or pellets. This process knows as wurster coater. In this process the spray is done inside a hollow cylinder and from the bottom of this cylinder the pellets are allowed in small quantity to enter the hollow cylindrical tube. Than the particles are passing the bottom spray guns in orderly manner quickly moving upward the tubes to avoid agglomeration. Once they are outside the wurster compartment, they move downward outside the compartment where they dry a another layer of coating can be supplied. Since the movement of the particle or pellets inside the wurster chamber totally controlled in ensures uniform.

High Precision Fluidize Pellets Coating & Drying Process Technology

Application & Process :

Prism Fluid Bed Processing involves Pellets and Granules coating and drying of particulate materials. It is ideal for heat sensitive and non heat sensitive products in Pharmaceuticals, Biotech, Nutraceuticals, Cosmetic, Chemicals, Biochemical, Food, Dairy, Confectionery, Agrochemical, Herbals, Ceramics, Detergents and Pharmaceuticals Institutes.

The equipment is use application for following process.

1. Aqueous or Solvent based solutions or suspensions
2. Enteric Release coatings
3. Controlled release coatings.
4. Fine particle coatings
5. Active layering.

Depending on the application required Prism fluid bed Equipment can be configured into designs as follows :

Fluid Bed Equipment with Wurster Coater Bottom Spray for Granules Coating or Pellet Coating :This process is used to apply a coating to the granules or pellets. This process knows as wurster coater. In this process the spray is done inside a hollow cylinder and from the bottom of this cylinder the pellets are allowed in small quantity to enter the hollow cylindrical tube. Than the particles are passing the bottom spray guns in orderly manner quickly moving upward the tubes to avoid agglomeration. Once they are outside the wurster compartment, they move downward outside the compartment where they dry another layer of coating can be supplied. Since the movement of the particle or pellets inside the wurster chamber totally controlled in ensures uniform.

Salient Features :

• Design is cGMP - Current Good Manufacturing Practices compliance.
• All contact parts AISI 316 & non contact parts AISI 304.
• High Mixing Precision, Short Batch Time, Problem free Cleaning and Residue Free Discharge.
• Single piece construction & Integrated retarding chamber cum filter bag housing
• Wurster Coater- Bottom spraying system for Granules, Pellet & Tablet Coating.
• Different Batch size capacity model available.
• Granulation and Coating system with advance PLC controls system with MMI Touch screen.
• Spraying system with atomized spraying gun and high precise flow peristaltic pump.
• Sampling pot on product container.
• Pneumatic Sealing of Filter Bag and Product container by inflatable silicon rubber tube.
• Inlet Air handler with Air Filter- Micro and HEPA and Heat Exchanger.
• Dual speed mixing impeller for mixing and intensify chopper for granulating.

Tablet Press tooling cleaning & Polishing

Application & Process :

For maximizing the life of table press tooling, this is only possible through efficient use and tacking care for good maintenance of tooling as well as tablet press. Prism offeredpunch polishing kitto table press tool clean and polishing. The proper & perfect use of tooling is minimized maintenance problem of tablet compression.

Prismpunch polishing kitis consist of motorized polishing machine with various type of polishing wheel, wire brush wheel, polishing media, fine emery paste and cleaning powder. For cleaning and polishing of critical areas of punches and dies, punch tip, embossing lettering and die bore with the help of number of components provided with tool polishing kit box. Also burrs on tips edges and dent marks on tips face can be remove by this polishing kit.

Salient Features :

• Designed according to TSM - Tablet Specification Manual.
• Tool clean is a comprehensive kit for tablet punch and die polishing to enhance life span of tablet tooling.
• Maintaining the tooling also minimizes many compression problems such as variations in tablet weight, thickness, picking, sticking, and capping of tablets.
• Elements of Punch polishing kit.
  • Double end polisher with buff wheels
  • Micro polishing powder.
  • Diamond Paste Syringe.
  • Buffing media.
  • Felt bobs.
  • Emery Roll.
  • Nylon brush wheels
  • Brass brush wheels
  • Punch Guide Brushes B and D Tooling (Nylon / brass)
  • Eye Glass
  • Steel Box.
  • Lapping sticks.

Ointment / Cream / Tooth Paste / Gel Manufacturing Plant

Semi solid manufacturing Plants are ideal tools for the pharmaceutical & cosmetic industries for the production ofOintment, Cream, Lotion, Gel, Tooth Paste& emulsions &homogenization.

Fully automatic Ointment, Cream, Tooth Paste , Gel manufacturing plant consisting of

• Pre determined water phase vessel.
• Pre determined oil, wax, petroleum jelly phase vessel.
• Vacuum Homogenizer Mixer vessel.
• Vacuum Pump
• Storage vessel
• Interconnecting pipeline.
• Transfer Pumps (Bump Pump, Lobe Pump & Metering pumps)
• Integrated automatic control panel.
• Working Platform

Design Features :

• Design compliance with cGMP
• Integrated Cleaning in Place-CIP.
• Sterilizing In Place-SIP as an Option.
• Batch Size
• Available model 50 Liter to 5000 Liter working Capacity.
• Materials
• Product Contact AISI 316L.
• Food Grade silicon rubber for seal.
• Water Phase Vessel
• Jacket for heating & cooling.
• Heating Jacket Pressure (4 bar).
• Heating by steam or hot water circulation.
• Propeller stirring with top mounting.
• Temperature controller & safety pressure Valve.
• Bottom discharge with valve.
• Wax Phase Vessel
• Jacket for heating & cooling.
• Heating Jacket Pressure (4 bar).
• Heating by steam or hot water circulation.
• Propeller stirring with top mounting.
• Temperature controller & safety pressure Valve.
• Bottom discharge with valve.
• Manufacturing Vacuumize Homogenizer Vessel.
• Jacket for heating & cooling.
• Vacuumize process.
• Vessel Inside Pressure (-1 /+2 Bar)
• Heating Jacket Pressure (-1 /+6 bar)
• Heating by steam or hot water circulation.
• Agitator mixer with self pressure Teflon scrapper.
• Scrapper cleanly working on both side.
• High speed Homogenizer with toothed Rotor - stator type.
• RPM sleeplessly with variable speed drive for agitator & Homogenizer.
• High shear & pressurization of the homogenizer.
• Thus homogenization of high viscosities up to 400.000 mPas.
• Homogenizer mounted on lower position in the centre of vessel.
• Top lid with motorized top lid for lifting & lowering.
• Safety Interlock process with limit switch.
• Connection for Vacuum, Charging, Eye glass window, Light glass, CIP, SIP, Pressure gauge & safety valve.
• Temperature controller & safety pressure Valve.
• Bottom discharge with valve.
• Vacuum System
• Water Ring Vacuum Pump.
• Vacuum gauge & Vacuum relief valve.
• Storage Vessel
• Skid type storage vessel.
• Bottom cone is Jacket for heating.
• Inter Connecting Pipe
• Inter connecting Pipe line of all vessel for transfer Water, Wax & products.
• Recirculation in manufacturing vessels.
• Vacuum connecting pipe.
• Working Platform
• Rigid structure with anti slipping embossed plat.
• Made from AISI 304.
• Controls & Visualization
• Electric Controls with digital display.
• Optional PLC Controls with HMI Touch screen.
• RPM and Process time entries.
• Temperature controls- Heat/cool.
• Vacuum start- Stop.
• Integrated Data Recording for batch.
• Safety Features
• Emergency stop button
• Safety vacuum relief valve & Indicator Gauge.
• Safety Pressure Valve.
• Limit switch at top lid

Dispersing, Suspending, Emulsifying & Homogenizing Technik for Liquid and Paste

Application & Process :

At PRISM, We design and manufacture a wide range ofagitatorsfor liquids and Paste for all process in the pharmaceutical, chemical, food, cosmetics and similar industries.Agitatorsare provided with different types of agitation components for process such as mixing, blending, dissolution, dispersion, homogenization, reaction, fermentation, oxidation, digestion and emulsification of liquid, paste, ointment, solution, viscous material and solid-liquid.

Agitatorsare designed and adapted to any vessel shape and can be implemented with or without lower support. Different types of blades can be combined depending on the process requirements. The sealing system are designed and adapted depending on the requirement of the various process and start from simple retainers to double mechanical seals. Agitators are available with different type of mounting as per suitability of the process and users requirements.

Different types of blades can be combined depending on the process requirements and various conditions including the stirring objective, tank shape, rotating speed, viscosity, mixing blades of different configurations should be applied for different operating objectives. Different mixing blades follow various specifications to design and select the configurations of the blades. The ratio of the blade to the inner diameter of the tank, angular speed of the blade top, viscosity change during mixing process and the range of the flow volume are the factors to be considered. There are various types of blade mixer and can be categorized into axial flow and radial flow according to the flow pattern of the fluid in the tank. The main factors affecting mixing performance are as below and the commonly used configurations are listed for reference:

1. Shape, diameter, sweep back angle and slant angle of the mixer blade
2. Number of layers and the vertical position of the mixer blade where it is installed
3. Rotating speed of the mixer blade
4. Shape, inner volume, number of baffles and outline dimensions of the mixing tank
5. Batch operation or continuous operation.

Agitators available with different type of drives and speeds with direct motor and with gear drive as per process requirements. Agitators are suitable for mixing volumes 5 liters to 10, 000 liters.

Salient Features :

• Design is cGMP - Current Good Manufacturing Practices compliance.
• All contact parts AISI 316 & non contact parts AISI 304.
• Capacity available for volume of 5 liters to 5, 000 liters.
• Available various different type of mixing blade.
• Available different mounting of stirrer assembly.1. Wall mounting2. Telescopic Stand3. Top of the vessels / Tanks.4. Bottom of the Vessels / Tanks.
• Can be provided Variable Speed Drive for stirrer by VFD.
• Option available for Explosion proof motor and controls panel.

Application & Process :

Prism has been designed & manufacturing preparation vessels and has consolidated a process knowledge concerning sterile injectable solution, dispersions, ophthalmic products, syrup and suppositories.

Preparation Vessels & Tank :

• Extremely hygienic processing.
• Least manual handling.
• Design compliance with cGMP
• Capacity up to 10, 000 Liter.
• Product Contact AISI 316L
• Atmospheric, Vacuum or Pressure Operation.
• Jacket for heating & cooling.
• Vessel Inside Pressure (-1 /+2 Bar)
• Heating Jacket Pressure (-1 /+6 bar)
• Heating by steam or hot water circulation.
• Thermal Insulated.
• Mechanicals or Electro polishing of internal surface.
• Welded, flanged or hinged type cover
• Integrated Cleaning in Place-CIP.
• Sterilizing In Place-SIP as an Option.
• Portable execution on request.
• Validation protocols & Instrumentation celebration.

Variable Speed Agitation :

• Agitator can be top or bottom driven or magnetically driven.
• Propeller type, Anchor type provided with High speed disperser or rotor-stator homogenizer.
• Single or double mechanical seal.

Fully automatic Liquid Syrup Manufacturing Plant consisting of :

• Sugar Charging / Transfer System.
• Sugar Melting Vessel with mixing stirrer.
• Basket Filter & Transfer Pump.
• Syrup Manufacturing Vessel with stirrer.
• Inline Homogenizer.
• Zero Hold up Filter press.
• Storage Tank with stirrer.
• Interconnecting pipeline.
• Transfer Pumps.
• Integrated automatic control panel.
• Working Platform.

Turn Key Process Line :

• For production, filtration, transfer and storage solution.
• Pre reparation vessels.
• Inline homogenizer.
• Inter Connecting Pipe
• Solid or sugar Charging System
• Working Platform.

Automation available, appropriate for the intended process function, including CIP and SIP :

• Controls of all function by PLC Controls with HMI Touch screen.
• Level controls by means of capacitance probe or electronic load cells.
• Digital indication and controls of all process parameters for Process time, agitator speed, temperature, pressure & level.