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Pancuronium (pancuronium bromide), The chemical name is dibromide (1, 1 - [3 , 17 -diacetyloxyl-5 -androsterane-2 , 16 -diyl] double [1-methylpiperidine]), a synthetic long-acting non-depolarized muscle relaxant in bisquaternary ammonium steroid, it is the first muscle relaxant used in ICU, its effect is 4-5 times stronger than right-cone, and has a blocking effect on all M choline receptors in the body. It is mainly used as an adjuvant to general anesthesia for endotracheal intubation during general anesthesia and muscle relaxation during surgery. This product has the characteristics of no histamine release, no ganglion block, and no causing hypotension Appearance and properties: white to almost white crystalline powder, no odor Melting point: 214-217 C synthetic method The following compounds react with isoprenol acetate, esterification, then oxyoxyperbenzoic acid, potassium hydroxide hydrolysis, and make one of the epoxens ring base, then react with piperidine, sodium borohydride reduction, acetylation, and finally react with two molecules of methyl bromide, quaternary ammonium into salt to get bromide. pay attention to This product is easy to cause the salivary gland secretion increase, atropine can be used This product can increase the heart rate, increase hypertension, hypertension with caution
Mr. Mintoo Kumar Gupta (Hish Resources Group)
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