Antihistamines

Our product range contains a wide range of Levocetirizine Dihydrochloride, Loratadine, Ketotifen Fumarate, Chlorpheniramine Maleate and Mizolastine

Levocetirizine Dihydrochloride

Supplied By UMA Brothers, India

We are offering levocetirizine dihydrochloride.Levocetirizine dihydrochloride is the dihydrochloride salt form of the active levorotatory enantiomer of cetirizine, levocetirizine; a third generation, non-sedating, selective histamineh1 receptor antagonist, with antihistamine, anti-inflammatory and potential anti-angiogenic activities. Levocetirizine competes with endogenous histamine for binding at peripheral h1-receptor sites on the effector cell surface. This prevents the negative symptoms associated with histamine release & an allergic reaction. In addition, as histamine plays an important role in angiogenesis during an allergic inflammatory reaction, blocking the action of histamine may modulate the expression of proangiogenic factors and thus may prevent angiogenesis. As a third-generation histamine h1 receptor antagonist, levocetirizine has fewer side effects than most second-generation antihistamines. synonyms: 2-[2-[4-[(r)-(4-chlorophenyl)-phenylmethyl] piperazin-1-yl] ethoxy] acetic acid; dihydrochloridecas number: 130018-87-0, mol. Formula: c21h27cl3n2o3, mol.weight: 461.81levocetirizine dihydrochloride is a white crystalline solid. It is soluble in water with melting range of 215c to 220c.Standard: offered of pharmaceutical grade bpuspep packing: offered in export worthy packing of 25 kilos or as per our customer requirements

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Loratadine

Supplied By UMA Brothers, India

We are offering loratadine.Loratadine is a second-generation histamine h1 receptor antagonist used in the treatment of allergic rhinitis and urticaria. Unlike most classical antihistamines (histamine h1 antagonists) it lacks central nervous system depressing effects such as drowsiness.Loratadine is a piperidine histamine h1-receptor antagonist with anti-allergic properties and without sedative effects. Loratadine blocks the h1 histamine receptor and prevents the symptoms that are caused by histamine activity on capillaries, bronchial smooth muscle, and gastro- intestinal smooth muscle, including vasodilatation, increased capillary permeability, bronchoconstriction &spasmodic contraction of gastro- intestinal smooth muscle. Loratadine does not cross the blood-brain barrier and does not cause central nervous system effects. synonyms: ethyl 4-(8-chloro-5, 6-dihydrobenzo [1, 2] cyclohepta [2, 4-b] pyridin-11-ylidene) piperidine-1-carboxylatecas number: 79794-75-5, mol. Formula: c22h23cln2o2, mol.weight: 382.88loratadine is a white crystalline solid. It is soluble in dmso (50 mgml), ethanol (77 mgml at 25 c), water (

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Ketotifen Fumarate

Supplied By UMA Brothers, India

We are offering ketotifen fumarate.Ketotifen fumarate is a cycloheptathiophene blocker of histamine h1 receptors and release of inflammatory mediators. It has been proposed for the treatment of asthma, rhinitis, skin allergies, and anaphylaxis.Ketotifen fumarate is the fumarate salt of ketotifen, a cycloheptathio- phene derivative with anti-allergic activity. Ketotifen selectively blocks histamine (h1) receptors and prevents the typical symptoms caused by histamine release. This agent also interferes with the release of inflammatory mediators from mast cells involved in hypersensitivity reactions, thereby decreasing chemotaxis and activation of eosinophils. synonyms: (e)-but-2-enedioic acid; 10-(1-methylpiperidin-4-ylidene)-5h-benzo [1, 2] cyclohepta [3, 4-b] thiophen-4-onecas number: 34580-14-8, mol. Formula: c23h23no5s, mol.weight: 425.5ketotifen fumarate is off-white solid powder. It is soluble in water (10 mgml), dmso (100 mm), and methanol with melting range of 152c to 153c.Standard: offered of pharmaceutical grade bpuspep packing: offered in export worthy packing of 25 kilos or as per our customer requirements

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Chlorpheniramine Maleate

Supplied By UMA Brothers, India

We are offering chlorpheniramine maleate.Chlorpheniramine maleate is a histamine h1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics it generally causes less drowsiness and sedation than promethazine.Chlorpheniramine maleate is a synthetic alkylamine derivative used in allergic reactions, hay fever, rhinitis, urticaria, and asthma, antihistamine chlorpheniramine maleate acts as a competitive histamine h1 receptor antagonist, and displays anticholinergic and mild sedative effects as well. synonyms: (z)-but-2-enedioic acid; 3-(4-chlorophenyl)-n, n-dimethyl-3-pyridin-2-ylpropan-1-aminecas number: 113-92-8, mol. Formula: c20h23cln2o4, mol.weight: 390.86chlorpheniramine maleate is an odorless white crystalline solid or white powder with a bitter taste. It is soluble in water, dmso, and methanol with melting range of 130cto 135c.Standard: offered of pharmaceutical grade bpuspep packing: offered in export worthy packing of 25 kilos or as per our customer requirements

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Mizolastine

Supplied By UMA Brothers, India

We are offering mizolastine.Mizolastine is a non sedating antihistamine exhibiting other antiallergic benefits which is effective for hay fever (seasonal allergic rhinitis) and chronic idiopathic urticaria. Other indications include perennial allergic rhinoconjunctivitis (an allergic reaction which affects the eyes as well as the nasal passages). It shares similarities with other antihistamines in relation to its mode of action, due to it acting as an antagonist of the histamine receptors and blocking the histamine from activating its receptors. This is one of the main ways in which it can neutralize allergy symptoms and episodes of allergic hives or nettle rash. synonyms: 2-[[1-[1-[(4-fluorophenyl) methyl] benzimidazol-2-yl] piperidin-4-yl]-methylamino] -1h-pyrimidin-6-onecas number: 108612-45-9, mol. Formula: c24h25fn6o, mol.weight: 432.49mizolastine is a white solid powder. It is sparingly soluble in water (13 mg1 at neutral ph) but much more soluble at acidic ph (11 g1 at ph 3) with melting range of 225c to 228c. standard: offered of pharmaceutical grade bpuspep packing: offered in export worthy packing of 25 kilos or as per our customer requirements

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Ashok Shah (Uma Brothers)
C-110, Bhaveshwar Plaza, 189, Lbs Marg, Ghatkopar West., Mumbai, Maharashtra - 400086, India
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