Uma Brothers - Anti Cancer Medicine

We are offering busulfan.An alkylating agent having a selective immunosuppressive effect on bone marrow it has been used in the palliative treatment of chronic myeloid leukemia (myeloid leukemia, chronic), but although symptomatic relief is provided, no permanent remission is brought about. According to the fourth annual report on carcinogens (ntp 85-002, 1985), busulfan is listed as a known carcinogen.Busulfan is an alkylating drug. The mechanism of action of busulfan is as an alkylating activity.Busulfan is a synthetic derivative of dimethane-sulfonate with antineoplastic and cytotoxic properties. Although its mechanism of action is not fully understood, busulfan appears to act through the alkylation of dna. Following systemic absorption of busulfan, carbonium ions are formed, resulting in dna alkylation and dna breaks and inhibition of dna replication and rna transcription. synonyms: 4-methylsulfonyloxybutyl methanesulfonatecas number: 55-98-1, mol. Formula: c6h14o6s2, mol.weight: 246.3busulfan is a white needles powder. It is soluble in acetone, 100% ethanol or dmso; insoluble in water with melting range of 114c to 117c.Standard: offered of pharmaceutical grade bpuspep packing: offered in export worthy packing of 25 kilos or as per our customer requirements

We are offering methotrexate.Methotrexate is an antineoplastic antimetabolite with immunosup- pressant properties. It is an inhibitor of tetrahydrofolate dehydro- genase & prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of dna. Methotrexate is a folate analog metabolic inhibitor. The mechanism of action of metho- trexate is as a folic acid metabolism inhibitor.Methotrexate is an antimetabolite and antifolate agent with antineo- plastic & immunosuppressant activities. Methotrexate binds to & inhibits the enzyme dihydrofolate reductase, resulting in inhibition of purine nucleotide and thymidylate synthesis and, subsequently, inhibition of dna & rna syntheses. Methotrexate also exhibits potent immunosuppressant activity although the mechanism(s) of actions is unclear. synonyms: (2s)-2-[[4-[(2, 4-diaminopteridin-6-yl) methyl-methylamino] benzoyl] amino] pentanedioic acidcas number: 59-05-2, mol. Formula: c20h22n8o5, mol.weight: 454.44methotrexate is a yellow crystaline powder. It is soluble in dmso (100 mm), and water (

We are offering tamoxifen.Tamoxifen is an estrogen agonistantagonist. The mechanism of action of tamoxifen is as a selective estrogen receptor modulator one of the selective estrogen receptor modulators with tissue-specific activities. Tamoxifen acts as an anti-estrogen (inhibiting agent) in the mammary tissue but as an estrogen (stimulating agent) in cholesterol metabolism, bone density &cell proliferation in the endometrium.tamoxifen base is an antineoplastic nonsteroidal selective estrogen receptor modulator (serm). Tamoxifen competitively inhibits the binding of estradiol to estro- gen receptors, thereby preventing the receptor from binding to the estrogen-response element on dna. The result is a reduction in dna synthesis & cellular response to estrogen. In additiontamoxifen up-regulates the production of transforming growth factor b (tgfb), a factor that inhibits tumor cell growth & down-regulates insulin-like growth factor 1 a factor that stimulates breast cancer cell growth. synonyms: 2-[4-[(z)-1, 2-diphenylbut-1-enyl] phenoxy]-n, n-dimethyle thanaminecas number: 10540-29-1, mol. Formula: c26h29no, mol.weight: 371.51tamoxifen is a white crystalline solid powder. It is soluble in dichloromethane with melting range of 97c to 98c. standard: offered of pharmaceutical grade bpuspep packing: offered in export worthy packing of 25 kilos or as per our customer requirements

We are offering hydroxycarbamide.Hydroxycarbamide is an antineoplastic agent that inhibits dna synthesis through the inhibition of ribonucleoside diphosphate reductase. Hydroxyurea is an antimetabolite. The chemical classification of hydroxyurea is urea.Hydroxycarbamide is an odorless or almost odorless white to off-white crystalline solid tasteless. synonyms: hydroxyureacas number: 127-07-1, mol. Formula: ch4n2o2, mol.weight: 76.05hydroxycarbamide is a white to off-white crystalline powder. It is very soluble in water, soluble in hot alcohol, insoluble in ethanol and benzene with melting range of 135c to 140c.Standard: offered of pharmaceutical grade bpuspep packing: offered in export worthy packing of 25 kilos or as per our customer requirements