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Api Intermediate

Our product range comtains a wide range of Simvastatin, Pharmaceutical Intermediates, Candesartan, pentoxifylline and Colchicine

Simvastatin

  • Supplied By UMA Brothers, India

We are offering simvastatin is a derivative of lovastatin and potent competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme a reductase (hydroxy methylglutaryl coa reductases), which is the rate-limiting enzyme in cholesterol biosynthesis. It may also interfere with steroid hormone production. Due to the induction of hepatic ldl receptors, it increases breakdown of ldl cholesterol. Simvastatin is a hmg-coa reductase inhibitor. The mechanism of action of simvastatin is as a hydroxy methylglutaryl-coa reductase inhibitor. Simvastatin is a lipid-lowering agent derived synthetically from a fermentation product of the fungus aspergillus terreus. Hydrolyzed in vivo to an active metabolite, simvastatincompetitively inhibits hepatic hydroxymethyl-glutaryl coenzyme a (hmg-coa) reductase, the enzyme which catalyzes the conversion of hmg-coa to mevalonate, a key step incholesterol synthesis. This agent lowers plasma cholesterol and lipoprotein levels, and modulates immune responses by suppressing mhc ii (major histocompatibility complex ii) on interferon gamma-stimulated, antigen-presenting cells such as human vascular endothelial cells. synonyms: [(1s, 3r, 7s, 8s, 8ar)-8-[2-[(2r, 4r)-4-hydroxy-6-oxooxan-2-yl]ethyl]-3, 7-dimethyl-1, 2, 3, 7, 8, 8a-hexahydronaphthalen-1-yl] 2, 2-dimethylbutanoate cas number: 79902-63-9, mol. Formula: c25h38o5, mol.weight: 418.57 simvastatin is a white solid powder. It is soluble in dmso (>25 mgml), ethanol (>25 mgml), water (0.03 mgl), and methanol with melting range of 127°c to 132°c. standard: offered of pharmaceutical grade bpuspep packing: offered in export worthy packing of 25 kilos or as per our customer requirements

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Pharmaceutical Intermediates

  • Purity 99.9%
  • Packing Offered in Export Worthy Packing
  • CAS NO 61825-94-3
  • CAS NO. 97-63-2
  • Molecular Weight 862.05
  • Nicotinic Acid 59-67-6
  • Moisture 0.2%max
  • Ash content 0.4%max
  • Supplied By UMA Brothers, India

Details 3-amino-4-methylamino-benzoic acid-n-(2-pyridyl)-n-(2- ethoxycarbonylethyl)-amide (212322-56-0) N-(4-cynophenyl)-glycine (42288-26-6) Ethyl 3-(2-((4-cyanophenylamino) methyl)-1-methyl-n- (pyridine-2-yl)-1h-benzo[d]imidazole-5- carboxamido) propanoate (211915-84-3) 2-(n-boc)-aminothiazole-5-carboxylic acid (302964-02-9) 2-amino-n-(2-chloro-6-methylphenyl)thiazole-5-carboxamide (302964-24-5) N-(2-chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl) amino]-5- thiazole carboxamide (302964-08-5) 4, 6-dichloro-2-methylpyrimidine (1780-26-3) 3-(n-methyl-n-pentyl amino) propionic acid hcl (625120-81-2) Etyl 2-(2-aminothiazol-4-yl) acetate (53266-94-7) 2-amino-4-thiazole acetic acid (29676-71-9) 2-amino-4-thiazole acetic acid hydrochloride (521284-21-9) 2-(4-nitrophenyl) ethanamine hydrochloride (29968-78-3) (r)-2-(4-nitrophenethylamino)-1-phenylethanol hydrochloride (521284-21-9) (r)-2-(4-aminophenethylamino)-1-phenylethanol hcl (521284-22-0) [2-(4-aminophenyl) ethyl] carbamic acid tert-butyl ester (94838-59-2) (r)-4-nitro phenethylamino-(2- hydroxy-2-phenylethyl)-tert-butyl carbamate (223673-35-6) 1, 2, 3, 9-tetrahydro-9-methyl-4(h)-carbazol-4-one (27387-31-1) 3-[(dimethylamino) methyl]-1, 2, 3, 9-tetrahydro-9-methyl-4hcarbazol- 4-one hcl (119812-29-2) 11-(piperazine-1-yl)dienzo[b, f][1, 4]thiazepine hydrochloride (11974-74-4) 3-quinuclidinone hydrochloride (1193-65-3) (3ar, 4s, 6r, 6as)-6-aminotetrahydro-2, 2-dimethyl-4h-cyclopenta-1, 3-dioxol-4-ol(cas 155899-66-4)

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Candesartan

  • Supplied By UMA Brothers, India

We are offering candesartan. Candesartan is an angiotensin 2 receptor blocker. The mechanism of action of candesartan is as an angiotensin 2 receptor antagonist. Candesartan is a synthetic, benzimidazole-derived angiotensin ii receptor antagonist prodrug with antihypertensive activity. candesartan selectively competes with angiotensin ii for the binding of the angiotensin ii receptor subtype 1 (at1) in vascular smooth muscle, blocking angiotensin ii-mediated vasoconstriction and inducing vasodilatation. In addition, antagonism of at1 in the adrenal gland inhibits angiotensin ii-stimulated aldosterone synthesis and secretion by the adrenal cortex; sodium and water excretion increase, followed by a reduction in plasma volume and blood pressure. synonyms: 2-ethoxy-3-[[4-[2-(2h-tetrazol-5-yl) phenyl] phenyl] methyl] benzimidazole-4-carboxylic acid cas number: 139481-59-7, mol. Formula: c24h20n6o3, mol.weight: 440.45 candesartan is a colourless crystalline solid powder. It is soluble in water with melting range of 183°cto 185°c. Standard: offered of pharmaceutical grade bpuspep packing: offered in export worthy packing of 25 kilos or as per our customer requirements

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Pentoxifylline

  • Supplied By UMA Brothers, India

We are offering pentoxifylline is a methylxanthine derivative with hemorrheologic & immunomodulating properties. Pentoxifylline inhibits phosphodiesterase, resulting in increased levels of cyclic adenosine monophosphate (camp) in erythrocytes, endothelium & the surrounding tissues. This leads to vasodilation, improves erythrocyte flexibility & enhances blood flow. In addition the increased level of camp in platelets inhibits platelet aggre- gation which may contribute to a reduction in blood viscosity. This agent also inhibits production of tumor necrosis factor-alpha & inter- feron-gamma while it induces th2-like (t-helper 2) cytokine production, thereby inhibiting th1-mediated (t-helper 1) inflammatory & autoimmune responses. Pentoxifylline is a blood viscosity reducer. The physiologic effect of it is by means of hematologic activity alteration. Threfore, methy lxanthine derivative that inhibits phosphodiesterase & affects blood rheology. It improves blood flow by increasing erythrocyte & leukocyte flexibility. It also inhibits platelet aggregation. Pentoxi fylline modulates immunologic activity by stimulating cytokine production. synonyms: 3, 7-dimethyl-1-(5-oxohexyl) purine-2, 6-dione cas number: 6493-05-6, mol. Formula: c13h18n4o3, mol.weight: 278.31 pentoxifylline is white to off-white solid powder. It is soluble in water (≥43 mgml), chloroform, methanol, and benzene with melting range of 104°c to 105°c. standard: offered of pharmaceutical grade bpuspep packing: offered in export worthy packing of 25 kilos or as per our customer requirements

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Colchicine

  • Supplied By UMA Brothers, India

We are offering colchicine. Colchicine is a major from colchicum autumnale l. And found also in other colchicum species. Its primary therapeutic use is in the treatment of gout, but it has been used also in the therapy of familial mediterranean fever (periodic disease). The mechanism of action of colchicine is as a cytochrome p450 3a4 inhibitor and p-glycoprotein interaction. Colchicine is an isolated from colchicum autumnale with anti-gout and anti-inflammatory activities. The exact mechanism of action by which colchicines exerts its effect has not been completely established. Colchicine binds to tubulin, thereby interfering with the polymerization of tubulin, interrupting microtubule dynamics, and disrupting mitosis. This leads to an inhibition of migration of leukocytes and other inflam- matory cells, thereby reducing the inflammatory response to deposited urate crystals. Colchicine may also interrupt the cycle of monosodium urate crystal deposition in joint tissues, thereby also preventing the resultant inflammatory response. Overall, colchicine decreases leuko- cyte chemotaxismigration and phagocytosis to inflamed areas, and inhibits the formation and release of a chemotactic glycoprotein that is produced during phagocytosis of uratecrystals. synonyms: n-[(7s)-1, 2, 3, 10 -tetramethoxy-9-oxo-6, 7-dihydro-5h-benzo [a] heptalen-7-yl] acetamide cas number: 64-86-8, mol. Formula: c22h25no6, mol.weight: 399.44 colchicine is a pale yellow scales or powder. It is soluble in ethanol (10 mgml), water (45.45 mgml), chloroform, dmso, and methanol with melting range of 142°c to 150°c. Standard: offered of pharmaceutical grade bpuspep packing: offered in export worthy packing of 25 kilos or as per our customer requirements

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Guaifenesin

  • Supplied By UMA Brothers, India

We are offering guaifenesin. Guaifenesin is an expectorant that also has some muscle relaxing action. It is used in many cough preparations. Guaifenesin is a glyceryl guaiacolate with expectorant effects. Guaifenesin increases respiratory tract mucus secretions, acts as an irritant to gastric vagal receptors and recruits efferent parasym- pathetic reflexes that cause glandular exocytosis. This agent reduces the viscosity of mucus secretion by reducing adhesiveness and surface tension as well as increasing hydration of mucus.guaifenesin promotes the efficiency of the mucociliary mechanism important in removing accumulated secretions from the upper and lower airway. synonyms: n-[2-[4-(cyclohexylcarbamoylsulfamoyl) phenyl] ethyl]-5-methylpyrazine-2-carboxamide cas number: 93-14-1, mol. Formula: c10h14o4, mol.weight: 198.22 guaifenesin is a white crystalline powder. It is soluble in water (50 mgml at 25 °c), methanol, dmso (40 mgml at 25 °c), dmf, and ethanol (50 mgml) with melting range of 77°c to 81°c. Standard: offered of pharmaceutical grade bpuspep packing: offered in export worthy packing of 25 kilos or as per our customer requirements

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Doxazosin Mesylate

  • Supplied By UMA Brothers, India

We are offering doxazosin mesylate. Doxazosin mesylate is a prazosin-related compound that is a selective alpha-1-adrenergic blocker. Doxazosin mesylate is the mesylate salt form of doxazosin, a quinazoline compound with smooth muscle relaxing activity. Doxazosin mesylate selectively antagonizes alpha-1-adrenergic receptors in smooth muscle of the bladder neck and prostate, thereby relaxing the smooth muscle and decreasing the obstruction and urethral resistance seen with benign prostate hyperplasia (bph). This may improve bph symptoms. This agent also blocks alpha-1-adrenergic receptors in peripheral vascular smooth muscle, which leads to vasodilatation and a subsequent decrease in peripheral vascular resistance. synonyms: [4-(4-amino-6, 7-dimethoxyquinazolin-2-yl) piperazin-1-yl]-(2, 3-dihydro-1, 4-benzodioxin-3-yl) methanone; methanesulfonic acid cas number: 77883-43-3, mol. Formula: c24h29n5o8s, mol.weight: 547.58 doxazosin mesylate is a white crystalline powder. It is soluble in water (slihgtly), dmso (15 mgml at 25 °c), ethanol (

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Indapamide

  • Supplied By UMA Brothers, India

We are offering indapamide. Indapamide is a benzamide-sulfonamide-indole derived diuretic that functions by inhibiting sodium chloride symporters. Indapamide is an indole derivative of chlorosulphonamide and a sulfamyl diuretic with antihypertensive activity. Indapamide may interact directly with the subunits of delayed rectifierpotassium channels, thereby blocking both slow and rapid k+ (iks and ikr) currents through the channels. Through the homeostasis mechanism in balancing total ion concentration (ca++, na+), it reduces vascular hyperreactivity and peripheral and arterial vascular resistance, possibly by inhibiting transmembrane ionic influx, probably calcium ions, and stimulating prostaglandin e2 synthesis, thereby causing vasodilatation. Indapamide exerts its diuretic effect by inhibiting reabsorption of sodium and chloride, primarily as a result of action on the cortical diluting segment of the renal distal tubule, thereby promoting urinary excretion of water and electrolytes. synonyms: 4-chloro-n-(2-methyl-2, 3-dihydroindol-1-yl)-3-sulfamoyl benzamide cas number: 26807-65-8, mol. Formula: c16h16cln3o3s, mol.weight: 365.83 indapamide is a white crystalline solid powder. It is soluble in methanol, dmso (73 mgml at 25 °c), ethanol (73 mgml at 25 °c), chloroform (slightly), and water (

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  • Ashok Shah
  • C-110, Bhaveshwar Plaza, 189, Lbs Marg, Ghatkopar West., Mumbai, Maharashtra - 400086, India
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